Type 2 diabetes is a chronic condition where the body can't use insulin effectively (insulin resistance) and over time can't produce enough. It accounts for ~90% of all diabetes and is largely preventable.

Summary

Type 2 = insulin resistance + progressive pancreas decline. Diagnosed by fasting glucose ≥ 126 mg/dL, HbA1c ≥ 6.5%, or OGTT 2-hr ≥ 200.

Symptoms

  • Excessive thirst, urination
  • Increased hunger
  • Unexplained weight loss (late)
  • Fatigue
  • Blurred vision
  • Slow-healing wounds
  • Frequent UTIs
  • Acanthosis nigricans

Diagnostic criteria (ADA)

TestThreshold
Fasting glucose≥ 126 mg/dL
HbA1c≥ 6.5%
OGTT 2-hr≥ 200 mg/dL
Random + symptoms≥ 200 mg/dL

Treatment: medications

ClassExampleEffect
BiguanideMetforminFirst-line
GLP-1SemaglutideSuppresses appetite
SGLT2EmpagliflozinCardio-protective
InsulinBasal/bolusWhen needed

Lifestyle treatment

  • 5–7% weight loss
  • 150 min/week cardio + 2 days resistance
  • Low-glycemic diet
  • 25–30 g fiber
  • Quit smoking
  • Stress management
  • 7–9 hours sleep

Type 1 vs Type 2

Type 1Type 2
MechanismAutoimmuneResistance + decline
OnsetChildhood-young40+
TreatmentInsulin alwaysLifestyle + meds
Prevalence5–10%90–95%

Frequently asked questions

Can type 2 diabetes be reversed?

In early stages (first 5 years), significant weight loss can lead to remission. Late-stage pancreatic decline isn't reversible.

Do I need insulin for type 2?

Rarely at start. Most patients do well on metformin + lifestyle. Insulin may be needed after 10–15 years.

Is type 2 diabetes fatal?

Not when well-managed. Complications affect lifespan if untreated.

What can't I eat?

No forbidden foods — portion and timing matter. Minimize sugary drinks, white flour, fried foods.


Medical disclaimer: This content is for educational purposes only and does not replace individual medical advice.